- science news Chemists discovered a new mechanism of action of a Vipera nikolskii venom neurotoxin
Scientists from the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS (IBCh RAS) with the participation of colleagues from the Institute of Human Morphology of RAMS and the Pirogov RSMU found that the enzyme phospholipase A2 from the Vipera nikolskii venom is able to adhere to lipid membranes (prototypes of cell membranes) and cause their aggregation, even if the activity of enzyme is specifically blocked. It turned out that this is due to the presence of two binding sites in the enzyme structure. Published in the journal Toxicon the results of the work help to understand how the multicomponent snakes’ venoms work.
- science news The researchers of the IBCh RAS took part at the international conference nAChR 2017
From 7 to 11 May the fourth international conference on nicotinic acetylcholine receptors (nAChR 2017) was held on the island of Crete (Greece) in which scientists from the Institute of Bioorganic Chemistry RAS took part. Together with other leading experts in the field of neurobiology associated with cholinergic transmission, they discussed the genetic, molecular, structural and cellular aspects of research and told what key trends in the development of this scientific area are actively supported now.
- science news Russian scientists study to control a neural network through infrared radiation
Researcher from the Institute of Bioorganic Chemistry of the Russian Academy of Sciences together with their colleagues have developed a method for stimulating neurons with infrared radiation. They implemented in mice neurons snake proteins that react to temperature – thermoreceptors. Published in Nature Communications journal results will help non-invasive stimulate neural networks in the deep layers of tissues in the body, as well as control the activity of other types of cells in living systems. In the future, it can help in the therapy of various nervous system diseases.
- science news Peptides from marine anemones gave analgesic effect
Researchers from the Institute of Bioorganic Chemistry RAS together with their colleagues have isolated the analgesic peptides Ms9a-1 and Ueq 12-1 from sea anemones, one of the most ancient predators on the planet. The ability of these substances to selectively enhance the activity of TRPA1 receptor opens up new opportunities for basic research and serves as a basis for the painkillers and anti-inflammatory drugs development. The research was supported by the Russian Science Foundation, and the results were published in the Journal of Biological Chemistry and Toxins.
- science news Scientists Train Mushrooms to Glow in all Colors of the Rainbow
Researchers at the Institute of Bioorganic Chemistry of the Russian Academy of Sciences (IBCh RAS), the Institute of Biophysics of the Krasnoyarsk Scientific Center SB RAS (IBP SB RAS) and the Pirogov Russian National Research Medical University, together with colleagues from Brazil and Japan, have drawn even closer to finally unveiling the secret of the mechanism that mushrooms use to glow. They successfully determined the structure of the molecule of oxyluciferin, a product of the luminescence reaction, from fungi (in this case, mushrooms were used), and also synthesized several artificial replicas of luciferin, which emit light of different colors. This groundbreaking work was funded by a grant from the Russian Science Foundation, RSF, and the results published in the journal Science Advances.
- science news Russian-German Symposium on Molecular Neurobiology Dedicated to the Memory of Eugene Grishin
On 5-9 April 2017, Russian-German symposium entitled ‘Molecular Neurobiology Today and Tomorrow’ dedicated to the memory of Academician Eugene Grishin took place at the Institute of Bioorganic Chemistry of the Russian Academy of Sciences. More than 30 leading scientists from Russia and Germany, specialists in neurobiology and neurochemistry, gathered at the Institute to honor the memory of Eugene Grishin and discuss the most pressing scientific issues, to which the academician had devoted his scientific career.
- science news The delegation of foreign journalists visited the Institute of Bioorganic Chemistry for the second time
The Institute of Bioorganic Chemistry (IBCh) visited by a delegation of foreign mass media representatives within the press tour "Russian Science Week", organized by the Moscow Institute of Physics and Technology and the "Communication Laboratory" project of the Russian Venture Company. The foreign journalists meeting from world-known mass media with the leading young specialists from IBCh held at February 28, 2017.
- science news Russian scientists have developed a mathematical model of the appearance of embryonic structures
Researchers at the Institute of Bioorganic Chemistry of the Russian Academy of Sciences, together with colleagues from the A.N. Belozersky Institute Of Physico-Chemical Biology of the Lomonosov Moscow State University and the P.N. Lebedev Physical Institute of the Russian Academy of Sciences, have proposed a new mechanism for the dynamic self-organization of spatial structures in embryogenesis. Using mathematical modeling methods, the researchers have demonstrated that this self-organization may be due to a significant difference in the diffusion of morphogen proteins, which occurs due to differently binding morphogens in the extracellular matrix. The results of this monumental research, which were published in the PLOS ONE Journal, create the preconditions for the development of other models that describe the appearance of the variety of forms in the early stages of development of an organism.
- science news Scientists Develop Cell-Analysis Method Much Faster Than Robotic Workstations
Researchers at the Institute of Bioorganic Chemistry of the Russian Academy of Sciences have collaborated with colleagues from other research institutions and created a microfluidic system for ultra-high-performance screening in double emulsion droplets. This breakthrough development can be used when studying the unique properties of singular living cells, and is 30 thousand times more productive that robotic workstations. At the same time, it greatly simplifies the work of researchers involved in determining the functionality of biological objects for the creation of medicinal products on their basis. The results of this research were published in the PNAS journal.
- science news Reports from Prof. V. Tsetlin's symposium, made during the integrated Forum in Dagomys were published (2016, 4-8th of October)
Reports form the section "Signaling ion channels from the spatial structure of physiological mechanisms" organized by Prof. V. Tsetlin made during the Forum, integrated V Congress of the Russian biochemists and V Congress of Physiologists in Dagomys (4-8 October 2016), were published on the page of the Institute of Bioorganic Chemistry in the channel YouTube. Videos of the lectures in English languages were published here.
- science news IBCh RAS will take part in the government program for pupils “Academic Class”
19th January the representatives of the Federal Agency for Scientific Organizations (FASO Russia), Department Education of Moscow and the heads of 17 schools of Moscow visited the Shemyakin&Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences. The purpose of the visit was a meeting where administration of the Institute and guests discussed a joint work within the framework of the FASO Russia project “Academic Class” (Science and Technology class in Moscow school).
- science news Lamprey helps scientists discover how the human brain appeared
December 27, 2016
Researchers at the M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences have collaborated with their colleagues from the A.N. Severtsova Institute of Ecology and Evolution in groundbreaking research work in which they discovered in lamprey the homeobox gene Anf / Hesx1, which is the most ancient gene in the existing living vertebrate. The research findings that they published in the Scientific Reports journal support the scientists’ hypothesis that the appearance of this gene in vertebrates created the conditions necessary for the emergence of the telencephalon.
- science news CMV Infection "disarms" the cell, inhibiting microRNA synthesis – Scientists
December 20, 2016
Scientists from the M.M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences collaborated with their colleagues from the D.I. Ivanovsky Institute of Virology in Moscow, the Kurchatov Institute, and researchers from the University of Lethbridge (Canada) in groundbreaking research work. They discovered that, in its early stages, CMV Infection "disarms" the cell, blocking its protective mechanisms by inhibiting the synthesis of miRNAs. The results of this study were published in the Cell Cycle journal, and may further be used as a basis for creating fundamentally new ways of combating viral Infection.
- science news Protein Complex FACT able to unwind Nucleosomes without expending Energy
December 7, 2016
A group of researchers from the Institute of Bioorganic Chemistry of the RAS and Moscow State University, in collaboration with the University of Utah, has for the first time successfully made use of the FRET-microscopy method to demonstrate the ability of nucleosomes to reversibly unwind under the action of FAST without expending any energy. The data obtained will in the future help scientists understand what role this protein complex plays in actively dividing cells in tumor tissues. The results of this breakthrough research were published in the Nature Structural & Molecular Biology journal.
- science news Scientists discover the effect of red light on fluorescent protein
November 21, 2016
Researchers at the M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, together with their colleagues from the Nizhny Novgorod State Medical Academy, have come up with a new method of switching the Dendra2 fluorescent protein from its green to its red form. This phenomenon avoid inflicting any damage to the cells under study, and can be used by a wide range of researchers. The research results were published in the Chemical Сommunications Journal.
- science news Nobel Laureate in Chemistry visited Russia with lectures
October 18, 2016
Arieh Warshel, laureate of the Nobel Prize in Chemistry 2013 for "the development of multiscale models for complex chemical systems", had made his first visit in Russia to take part in the Forum unifying the 5th Physiological Congress of CIS and 5th Congress of the Russian Biochemical Society (Dagomys, Sochi, October 4-9, 2016). Professor Warshel had gone by invitation of corresponding member of the RAS, deputy sci-director of the IBCh RAS Alexander Gabibov.
- science news Scientists have studied the role of sialic acid in cancer development
October 7, 2016
A group of researchers from the Institute of Bioorganic Chemistry of the Russian Academy of Sciences and Queen’s University (Canada), in conjunction with the Institute of Macromolecular Compounds of the Russian Academy of Sciences, has studied the role of sialic acid in cancer development. The results of their research showed that cancer cells can be manipulated by properly adjusting the acid’s levels, and this can possibly halt the spread of metastases. Their findings were published in the Oncotarget magazine.
- science news Computer simulates body reaction to heat
September 13, 2016
For the first time, scientists at the M.M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences have successfully used computer generated simulations to study the TRPV1-Receptor temperature activation phenomenon for higher organisms. Up to this point, it was impossible to achieve such results in silico experiments due to imperfections in the computer simulation models. The results of the experiment were published in the Scientific Reports journal.
- science news Russian Scientists have detected unusual behavior of the PIWIL2 gene “helpers”
July 15, 2016
A team of scientists from the Institute of Bioorganic Chemistry RAS have discovered new information on how the PIWIL2 human gene expresses itself. This breakthrough discovery shall help create a diagnostic marker for determining testicular germ cell tumors. The research findings suggest the interchangeability of the PIWIL2 “helpers”: the promoter of this gene is also able to act as an enhancer of the expression of another gene. The work, published in the PLoS ONE journal, helps expand the background knowledge in this field.
- science news How research into glowing fungi could lead to trees lighting our streets (The Guardian)
July 8, 2016
On a moonless night deep in a Brazilian rainforest the only thing you are likely to see are the tiny smears of light from flitting fireflies or the ghostly glow of mushrooms scattered around the forest floor. Both effects are the result of bioluminescence, the peculiar ability of some organisms to behave like living night-lights. (this text was pblished in The Guardian)
- science news Lynx1 protein competes with the amyloid peptide
July 4, 2016
A joint study on the Lynx1 protein that was conducted by researchers from the Institute of Bioorganic Chemistry of the Russian Academy of Sciences together with their colleagues from the universities of Copenhagen and Leipzig, has revealed that this protein competes with human nicotinic acetylcholine receptors for binding to amyloids, which are the main cause for the development of Alzheimer's disease. In the future, the protein could be used in the development of new treatment therapies or future combinations for the treatment of disease. The results of the experiment were published in the Neurobiology of Aging journal.