- science news Ras-dva: make regeneration great again
The researchers from Laboratory of molecular bases of embryogenesis recently hypothesised that the decrease of limb regeneration capacity in amniotes (reptiles, birds and mammals) could be caused by elimination in evolution of genes, encoding for important regulators of specific wound epithelium and blastema organization, which are used by excellent regenerating anamniotes (fish and amphibia). Using two anamniotic model organisms Danio rerio adult fishes and Xenopus laevis tadpoles the authors have shown the essential role of Ras-dva small GTPases in regulation of these processes, meanwhile their genes are eliminated in a stepwise manner during evolution till total absence in placental mammals. The obtained results support the hypothesis. The investigation is published in Scientific reports.
- science news A bright bantam: BrUSLEE – green fluorescent protein with the unique properties
Researchers from the Biophotonics lab of IBCH RAS (Anastasia Mamontova, Konstantin Lukyanov and Alexey Bogdanov) designed a new green fluorescent protein that combines high fluorescence brightness and short fluorescence lifetime. They used a semi-rational protein evolution approach. Their collaborators from Bach Institute of Biochemistry and Semenov Institute of Physical Chemistry helped with the time-resolved fluorescence analysis (FLIM) that allowed characterizing the physical properties of this perspective probe. Research has recently been published in the Scientific Reports.
- science news Antibiotic from the bear's mouth
Scientists from the Laboratory of biocatalysis developed a new microfluidics-based ultrahigh-throughput technology for the “deep functional profiling” of microbial communities and used it to search for bacteria producing new antibiotics in the microbiome of the Siberian bear's oral cavity. This methodology allowed them not only to find the antibiotic amicoumacin, elucidating the mechanisms of its biosynthesis and self-resistance, but also to investigate the spectrum of its activity at the level of various bacterial communities. The results published in PNAS will find numerous applications in the field of antibiotic discovery and will help to solve the problem of antibiotic resistance.
- science news Visit of Delegation of Ministry of Science, Technology and Space of Israel
- science news Spider venom may help to stop neuronal death
Venoms of spiders and wasps contain acylpolyamines that act as high-affinity blockers of ionotropic receptors for glutamate, the main excitatory neurotransmitter in the human central nervous system (CNS). The first representative of acylpolyamines, argiopin from the venom of the orb-weaver spider Argiope lobata, was discovered in 1986 by Eugene Grishin’s team at IBCh RAS. Here, an international team of scientists, including a researcher from IBCh RAS, has used cryo-electron microscopy (cryo-EM) to determine the first atomic structure of an argiopin-glutamate receptor complex. This structure will help to design new drugs for treatment of neurodegenerative diseases. The study is published in Neuron.
- science news Fast and safe: new reversibly switchable fluorescent proteins for live-cell nanoscopy
Russian scientists together with colleagues from Sweden and the USA developed red fluorescent tags that are safe for nanoscopy in living cells. This work was funded by a grant from the Russian Science Foundation (RSF), and the results are published in Nature Methods journal.
- science news Genetically encoded fluorescent pH probe for precise monitoring of cellular biochemistry
One of the directions of the Molecular Technologies Laboratory is the development of new tools for bioimaging and optogenetics. Yulia Ermakova, Vsevolod Belousov and other lab members, in an article in Chemical Communications, describe a new member of SypHer family of genetically encoded pH indicators, SypHer3s.
- science news Spider venom will cure from paralysis
Scientists from IBCh RAS together with foreign colleagues discovered that a toxin from the venom of the spider Heriaeus melloteei may serve as a hit in drug discovery for hypokalemic periodic paralysis type 2. The disease is caused by mutations in the gene encoding voltage-gated sodium channels NaV1.4, characteristic of skeletal muscles. As a result of the mutations, these channels conduct aberrant currents, the muscles are unable to respond to the signals of the nervous system, and weakness develops followed by paralysis. Until now, there is no reliable medication for all cases of this disease. The results of the work are published in the Proceedings of the National Academy of Sciences of the USA (PNAS).
- science news Lindoldhamine can activate the human ASIC3 channel
Researchers from the Laboratory of Neuroreceptors and Neuroregulators (group leader - Sergei Kozlov) found alkaloid lindoldhamine in the leaves of the noble laurel, which can activate the human ASIC3 channel at physiological pH.
- science news Open call for research fellowships in Systems Biology
The Skoltech Center for Data Intensive Biomedicine and Biotechnology is proud to announce for the third time an open call for research fellowships in Systems Biology. Application period: 20 February 2018 to 15 March 2018 (Deadline: 23:59, Moscow time). The total amount of support is 630,000 rubles per year. Period: 3-year. Deadline: 15-03-2018 23:59 For more information on who is eligible to apply, how to apply, and available funding, please click here.
- ys-ad Video from the 42th Seminar of the Young scientists counsil
- science news Academician A.G. Gabibov and Professor J. Schlessinger handed over the Lomonosov Great Gold Medal to Professor Sidney Altman
October 13, 2017
Acting Director of the Institute of Bioorganic Chemistry RAS, President of the Russian Biochemistry and Molecular Biology Society, academician Alexander Gabibov and the head of the Pharmacology Department at Yale University, a member of the US National Academy of Sciences and a foreign member of the RAS, member of the International Advisory Board of Institute of Bioorganic Chemistry of the RAS Joseph Schlessinger on behalf of the President of the Russian Academy of Sciences awarded the Lomonosov Great Gold Medal to the laureate of 2016, Professor at Yale University, a member of the International Advisory Board of Institute of Bioorganic Chemistry RAS, Nobel Prize laureate Sidney Altman. Professor Altman has received the award "for outstanding contribution to the field of biochemistry of nucleic acids, the discovery of the catalytic activity of the nucleic acids and the creation of new biologically active substances."
- science news The international forum was held at the IBCh RAS
October 12, 2017
The Joint Life Sciences Forum, including the International Scientific Conference in bioorganic chemistry "XII conference dedicated to the Memory of Academician Yuri A. Ovchinnikov" and the VIII Russian Symposium "Proteins and Peptides" with a Young Scientists Competition, was held at the Institute of Bioorganic Chemistry RAS at 18-22 September, 2017. The leading foreign experts who visited the forum named it one of the main scientific events in the field of Life Sciences in the world in this year.
- science news Laboratory of the IBCh first in Russia received a foreign order for preclinical testing of substances by world standards
October 5, 2017
Laboratory of Biological Tests of the Branch of the Institute of Bioorganic Chemistry (BICh) received an order from a European company for preclinical animal studies, which will be conducted in accordance with world standards. Thus, for the first time, Russia will export high-tech services such as pre-clinical research for foreign countries.