Lindoldhamine can activate the human ASIC3 channel
Researchers from the Laboratory of Neuroreceptors and Neuroregulators (group leader - Sergei Kozlov) found alkaloid lindoldhamine in the leaves of the noble laurel, which can activate the human ASIC3 channel at physiological pH. They reported that acidification of the extracellular medium is not essential for the opening of this channel. Molecules, closely related to the structure of lindolhamine, are produced in the human body during the inflammation and can also activate and alter the functioning of acid-sensitive channels. Regulation of the intracellular synthesis pathways of these endogenous molecules can be a new therapeutic strategy for a novel therapeutic strategy for treatment of pain and inflammation.
- Fast and safe: new reversibly switchable fluorescent proteins for live-cell nanoscopy
Russian scientists together with colleagues from Sweden and the USA developed red fluorescent tags that are safe for nanoscopy in living cells. This work was funded by a grant from the Russian Science Foundation (RSF), and the results are published in Nature Methods journal.
- Genetically encoded fluorescent pH probe for precise monitoring of cellular biochemistry
One of the directions of the Molecular Technologies Laboratory is the development of new tools for bioimaging and optogenetics. Yulia Ermakova, Vsevolod Belousov and other lab members, in an article in Chemical Communications, describe a new member of SypHer family of genetically encoded pH indicators, SypHer3s.
- Spider venom will cure from paralysis
Scientists from IBCh RAS together with foreign colleagues discovered that a toxin from the venom of the spider Heriaeus melloteei may serve as a hit in drug discovery for hypokalemic periodic paralysis type 2. The disease is caused by mutations in the gene encoding voltage-gated sodium channels NaV1.4, characteristic of skeletal muscles. As a result of the mutations, these channels conduct aberrant currents, the muscles are unable to respond to the signals of the nervous system, and weakness develops followed by paralysis. Until now, there is no reliable medication for all cases of this disease. The results of the work are published in the Proceedings of the National Academy of Sciences of the USA (PNAS).
- International conference "Biomembranes - 2018" at MIPT
Dear Colleagues! We are very pleased to invite you to participate in the International Conference “BIOMEMBRANES 2018”, which will be held on October 1-5, 2018 at the Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, Moscow region, Russia.
- Seminar «Nutritional and pharmaceutical applications of bioactive compounds in plants»
VIII.6 (This event is over)
Dear colleagues, We invite you to the public seminar of Shela Gorinstein, Professor of Hebrew University of Jerusalem. It will take place on August 6 at 11 AM, in the conference hall on the 5th fl., IBCH RAS. The topic of the seminar is: «Nutritional and pharmaceutical applications of bioactive compounds in plants».
- The lecture by prof. Chandi C. Mandal Cancer biology basics. An intriguing link between cholesterol and tumorigenesis
VIII.2 (This event is over)
Thursday, 2 august, 15-00.Seminar room, bld. 34, stage 5. Chandi C. Mandal, PhD Associate Professor and Head Department of Biochemistry School of Life Sciences Central University of Rajasthan Dr. Mandal’s research interests: Finding the underlying molecular mechanism for cholesterol-induced cancer growth and Metastasis Investigating the molecular mechanism involved in cancer microcalcification and its prevention strategy Investigating the target identification for cold-mediated tumorigenesis Study for preventing mutation in mutation prone zones in cancer genome Identification of bioactive secondary metabolites for prevention of cancer metastasis Part 1. Cancer biology basics (15-00) Part 2. An intriguing link between cholesterol and tumorigenesis (15-40) Obesity, diabetes and hormonal imbalance have been linked with cancer incidence and/or mortality. Several findings have focused on high cholesterol as a cancer driving intrinsic factor. Although, this link has not yet been established well. This study aimed to find out whether elevation of cellular cholesterol promotes tumorigenesis. Our nationwide statistical analyses found an existence of positive correlation between cancer mortality rate and total average serum cholesterol of the population of a country. This positive relationship was also noticed in various anatomical site-specific cancers including thyroid, breast, ovary and others, except liver and cervical cancers. Moreover, tumor sample study found the higher expressions of cellular cholesterol regulatory genes (e.g. HMGCoR, LDLR) and elevated level of cholesterol in malignant breast cancer tissues as compared to benign tissues. Cell culture study documented that treatment of breast cancer cells with cholesterol increased cell proliferation and migration of breast cancer cells. Whereas, cholesterol depleting MBCD inhibited cell proliferation, EMT and stemness in breast cancer cells.