The staff of the Laboratory of structural biology of ion channels and the Science–Educational center for the first time studied the thermodynamics of the dimerization process of a β-hairpin peptide in the membrane-mimicking environment of detergent micelles using the example of the antimicrobial peptide (AMP) capitellacin of the marine polychaete Capitella teleta. The study also describes the mechanism of capitellacin action on bacterial membranes. The results of the work were published in the journal Biomolecules.

Ribosome biogenesis is a sophisticated time-ordered process, which adjusts the protein synthesis rate to consumption of nutrients and external stimuli. It begins with transcription of the ribosomal primary RNA precursor. 13.3 kB 47S (fig.) pre-rRNA processing is coupled with the sequential recruitment of ribosome biogenesis factors and non-coding RNAs as well as ordered coating of rRNA with ~80 ribosomal proteins during formation of the functional 60S and 40S ribosomal subunits.

The antiviral T-1105 and T-705 (Favipiravir) compounds are inactive prodrugs that undergo metabolic transformation into the active form through phosphoribosylation in vivo. The efficiency of this process in human cells is very low, making the production of the phosphoribosylated pyrazine-2-carboxamide derivatives in vitro is a worthy challenge.