J Med Chem, 2004, 47(14):3606-3614
Uncharged AZT and D4T derivatives of phosphonoformic and phosphonoacetic acids as anti-HIV pronucleosides
Two series of new lipophilic phosphonoformate and phosphonoacetate derivatives of AZT and d4T were synthesized and evaluated as anti-HIV agents. The efficacy of some of the synthesized compounds in cell cultures infected with HIV-1 was higher than that of the parent nucleosides and only slightly correlated to their stability in the phosphate buffer and human blood serum. The synthesized phosphonates are most probably prodrug forms of the corresponding nucleosides.
Scopus: 2-s2.0-3042636470
: 15214788
IBCH: 1426
Ссылка на статью в журнале: http://pubs.acs.org/doi/abs/10.1021/jm0310176
Кол-во цитирований на 03.2024: 33
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