Laboratory of membrane bioenergetics

NamePositionContacts
Michail Shahparonov, D.Scdepart. dir.shakhparonov@gmail.com+7(495)330-65-56
Tat'jana Korneenko, Ph.D.r. f.tvkorn@gmail.com+7(495)330-65-74
Nadine Antipova, Ph.D.r. f.nadine.antipova@gmail.com+7(495)330-65-74
Marat Pavliukov, Ph.D.r. f.marat.pav@mail.ru
Tatiana LarionovaPhD stud.iceberg987@yandex.ru
Pavel Alexandrovres. eng.

Former members:

Natalia Gevondyan, Ph.D.s. r. f.nmgevondyan@mail.ru
Marija Kostina, Ph.D.s. r. f.
Nikolay Pestov, Ph.D.s. r. f.ni-pest@yandex.ru
Ruslan Dmitriev, Ph.D.j. r. f.
Maksim Egorovj. r. f.

Selected publications

Michail Shahparonov

The role of protein regulators of splicing in the intercellular communication of tumor cells (2017-11-28)

A novel mechanism of communication between tumor cells mediated by intercellular transport of spliceosomes has been demonstrated. Investigation of clinical samples from patients with ovarian cancer, as well as primary cultures of human glioblastoma cells, allowed us to observe that, upon induction of apoptosis, many tumor cells secrete into the extracellular environment various components of the spliceosome, a ribonucleoprotein complex that splices RNA molecules in eukaryotes. During the early stages of apoptosis the spliceosomes are transported from the nucleus to the cytoplasm, and then are secreted inside membrane vesicles (exosomes). These vesicles can be captured by neighboring tumor cells, and the splicing proteins contained therein affect mRNA splicing in the recipient cells. This leads to the formation of different protein isoforms and the acquisition of a more aggressive and treatment-resistant phenotype of surviving tumor cells. One of the key players of this process was identified as the RBM11 protein, which is readily transferred between glioblastoma cells and regulates alternative splicing of important oncogenes such as MDM4 and CyclinD1.