Tat'jana V. Vinogradova

Ph.D. (biological sciences)


Senior research fellow (Laboratory of human genes structure and functions)

Phone: +7 (495) 330-65-47

E-mail: tv@ibch.ru

Selected publications

  1. Zinovyeva MV, Nikolaev LG, Kondratyeva LG, Vinogradova TV, Sverdlov ED (2018). Correlation between Expression of KLF5 and ZEB1 Transcription Factor Genes in Pancreatic Cancer. Dokl Biochem Biophys 481 (1), 219–221
  2. Vinogradova TV, Sverdlov ED (2017). PDX1: A unique pancreatic master regulator constantly changes its functions during embryonic development and progression of pancreatic cancer. Biochemistry (Mosc) 82 (8), 887–893
  3. Kondratyeva LG, Didych DA, Chernov IP, Kopantzev EP, Stukacheva EA, Vinogradova TV, Sverdlov ED (2017). Dependence of expression of regulatory master genes of embryonic development in pancreatic cancer cells on the intracellular concentration of the master regulator PDX1. Dokl Biochem Biophys 475 (1), 259–263
  4. Shepelev MV, Kopantzev EP, Vinogradova TV, Sverdlov ED, Korobko IV (2016). hTERT and BIRC5 gene promoters for cancer gene therapy: A comparative study. Oncol Lett 12 (2), 1204–1210
  5. Vinogradova TV, Chernov IP, Monastyrskaya GS, Kondratyeva LG, Sverdlov ED (2016). Cancer Stem Cells: Plasticity Works against Therapy. Acta Naturae 7 (4), 46–55
  6. Alekseenko IV, Snezhkov EV, Chernov IP, Pleshkan VV, Potapov VK, Sass AV, Monastyrskaya GS, Kopantzev EP, Vinogradova TV, Khramtsov YV, Ulasov AV, Rosenkranz AA, Sobolev AS, Bezborodova OA, Plyutinskaya AD, Nemtsova ER, Yakubovskaya RI, Sverdlov ED (2015). Therapeutic properties of a vector carrying the HSV thymidine kinase and GM-CSF genes and delivered as a complex with a cationic copolymer. J Transl Med 13 (1), 78
  7. Kuzmich AI, Tyulkina DV, Vinogradova TV, Sverdlov ED (2015). Pioneer transcription factors in normal development and carcinogenesis. Russ. J. Bioorganic Chem. 41 (6), 570–577
  8. Kondratyeva LG, Vinogradova TV, Chernov IP, Sverdlov ED (2015). Master Transcription Regulators Specifying Cell-Lineage Fates in Development As Possible Therapeutic Targets in Oncology. Genetika 51 (11), 1221–1233
  9. Vinogradova TV, Chernov IP, Monastyrskaya GS, Kondratyeva LG, Sverdlov ED (2015). Cancer stem cells: Plasticity works against therapy. Acta Naturae 7 (4), 46–55
  10. Kuzmich AI, Kopantsev EP, Vinogradova TV, Sverdlov ED (2014). Comparative activity of several promoters in driving NIS expression in melanoma cells. Mol Biol 48 (1), 121–129
  11. Shubin AV, Lunina NA, Shedova EN, Roshina MP, Demidyuk IV, Vinogradova TV, Kopantsev EP, Chernov IP, Kostrov SV (2013). Evaluation of the toxic effects evoked by the transient expression of protease genes from human pathogens in HEK293 cells. APPL BIOCHEM MICRO+ 49 (9), 750–755
  12. Kuzmich AI, Vvedenskii AV, Kopantzev EP, Vinogradova TV (2013). Quantitative comparison of gene co-expression in a bicistronic vector harboring IRES or coding sequence of porcine teschovirus 2A peptide. Russ. J. Bioorganic Chem. 39 (4), 406–416
  13. Shepelev MV, Korobko EV, Vinogradova TV, Kopantsev EP, Korobko IV (2013). LY294002 enhances expression of proteins encoded by recombinant replication-defective adenoviruses via mTOR- and non-mTOR-dependent mechanisms. Mol Pharm 10 (3), 931–939
  14. Demidyuk IV, Shubin AV, Gasanov EV, Kurinov AM, Demkin VV, Vinogradova TV, Zinovyeva MV, Sass AV, Zborovskaya IB, Kostrov SV (2013). Alterations in Gene Expression of Proprotein Convertases in Human Lung Cancer Have a Limited Number of Scenarios. PLoS One 8 (2), e55752
  15. Durymanov MO, Beletkaia EA, Ulasov AV, Khramtsov YV, Trusov GA, Rodichenko NS, Slastnikova TA, Vinogradova TV, Uspenskaya NY, Kopantsev EP, Rosenkranz AA, Sverdlov ED, Sobolev AS (2012). Subcellular trafficking and transfection efficacy of polyethylenimine- polyethylene glycol polyplex nanoparticles with a ligand to melanocortin receptor-1. J Control Release 163 (2), 211–219
  16. Alekseenko IV, Pleshkan VV, Kopantzev EP, Stukacheva EA, Chernov IP, Vinogradova TV, Sverdlov ED (2012). Activity of the Upstream Component of Tandem TERT/Survivin Promoters Depends on Features of the Downstream Component. PLoS One 7 (10), e46474
  17. Alekseenko IV, Kopantzev EP, Vinogradova TV, Sverdlov ED (2011). Bicistronic vector for combined expression of the HSVtk killer gene and cytokine GM-CSF gene in cancer cells. Dokl Biochem Biophys 439 (1), 174–177
  18. Pavlyukov MS, Antipova NV, Balashova MV, Vinogradova TV, Kopantzev EP, Shakhparonov MI (2011). Survivin monomer plays an essential role in apoptosis regulation. J Biol Chem 286 (26), 23296–23307
  19. Abrarova N, Simonova L, Vinogradova T, Sverdlov E (2011). Different transcription activity of HERV-K LTR-containing and LTR-lacking genes of the KIAA1245/NBPF gene subfamily. Genetica 139 (6), 733–741
  20. Kashkin KN, Musatkina EA, Komelkov AV, Tonevitsky EA, Sakharov DA, Vinogradova TV, Kopantsev EP, Zinovyeva MV, Favorskaya IA, Kainov YA, Aushev VN, Zborovskaya IB, Tonevitsky AG, Sverdlov ED (2011). Genes potentially associated with Cisplatin resistance of lung cancer cells. Dokl Biochem Biophys 438 (1), 147–150
  21. Kashkin KN, Musatkina EA, Komelkov AV, Sakharov DA, Trushkin EV, Tonevitsky EA, Vinogradova TV, Kopantzev EP, Zinovyeva MV, Kovaleva OV, Arkhipova KA, Zborovskaya IB, Tonevitsky AG, Sverdlov ED (2011). Genes Potentially Associated with Resistance of Lung Cancer Cells to Paclitaxel. Dokl Biochem Biophys 437 (1), 105–108
  22. Pleshkan VV, Alekseenko IV, Zinovyeva MV, Vinogradova TV, Sverdlov ED (2011). Promoters with cancer cell-specific activity for melanoma gene therapy. Acta Naturae 3 (2), 13–21
  23. Sverdlov ED, Vinogradova TV (2010). Core promoters as an example of the effect of whole-genome information on the evolution of views on molecular mechanisms of vital activity. Mol Biol 44 (5), 682–692
  24. Kuzmin D, Gogvadze E, Kholodenko R, Grzela DP, Mityaev M, Vinogradova T, Kopantzev E, Malakhova G, Suntsova M, Sokov D, Ivics Z, Buzdin A (2010). Novel strong tissue specific promoter for gene expression in human germ cells. BMC Biotechnol 10 (0), 58
  25. Abrarova ND, Stoukacheva EA, Pleshkan VV, Vinogradova TV, Sverdlov ED (2010). Functional analysis of the HERV-K LTR residing in the KIAA1245/NBPF subfamily genes. Mol Biol 44 (4), 552–558
  26. Kopantzev EP, Vayshlya NA, Kopantseva MR, Egorov VI, Pikunov M, Zinovyeva MV, Vinogradova TV, Zborovskaya IB, Sverdlov ED (2010). Cellular and molecular phenotypes of proliferating stromal cells from human carcinomas. Br J Cancer 102 (10), 1533–1540
  27. Zinovyeva MV, Monastyrskaya GS, Kopantzev EP, Vinogradova TV, Kostina MB, Sass AV, Filyukova OB, Uspenskaya NY, Sukhikh GT, Sverdlov ED (2010). Identification of some human genes oppositely regulated during esophageal squamous cell carcinoma formation and human embryonic esophagus development. Dis Esophagus 23 (3), 260–270
  28. Kashkin KN, Musatkina EA, Komelkov AV, Favorskaya IA, Trushkin EV, Shleptsova VA, Sakharov DA, Vinogradova TV, Kopantzev EP, Zinovyeva MV, Kovaleva OV, Zborovskaya IB, Tonevitsky AG, Sverdlov ED (2010). Expression profiling and putative mechanisms of resistance to doxorubicin of human lung cancer cells. Dokl Biochem Biophys 430 (1), 20–23
  29. Mityaev MV, Kopantzev EP, Buzdin AA, Vinogradova TV, Sverdlov ED (2010). Enhancer element potentially involved in human survivin gene promoter regulation in lung cancer cell lines. Biochemistry (Mosc) 75 (2), 182–191
  30. Anedchenko EA, Dmitriev AA, Krasnov GS, KondratEva OO, Kopantsev EP, Vinogradova TV, ZinovEva MV, Zborovskaya IB, Polotsky BE, Sacharova OV, Kashuba VI, Zabarovsky ER, Senchenko VN (2008). Downregulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1, and HYAL2 in non-small cell lung cancer. Mol Biol 42 (6), 859–869
  31. Mityaev MV, Kopantzev EP, Buzdin AA, Vinogradova TV, Sverdlov ED (2008). Functional significance of a putative Sp1 transcription factor binding site in the survivin gene promoter. Biochemistry (Mosc) 73 (11), 1183–1191
  32. Pleshkan VV, Vinogradova TV, Sverdlov ED (2008). Methylation of the prominin 1 TATA-less main promoters and tissue specificity of their transcript content. BIOCHIM BIOPHYS ACTA 1779 (10), 599–605
  33. Kopantzev EP, Monastyrskaya GS, Vinogradova TV, Zinovyeva MV, Kostina MB, Filyukova OB, Tonevitsky AG, Sukhikh GT, Sverdlov ED (2008). Differences in gene expression levels between early and later stages of human lung development are opposite to those between normal lung tissue and non-small lung cell carcinoma. Lung Cancer 62 (1), 23–34
  34. Vayshlya NA, Zinovyeva MV, Sass AV, Kopantzev EP, Vinogradova TV, Sverdlov ED (2008). Increased expression of BIRC5 in non-small cell lung cancer and esophageal squamous cell carcinoma does not correlate with the expression of its inhibitors SMAC/DIABLO and PML. Mol Biol 42 (4), 579–587
  35. Illarionova AE, Vinogradova TV, Sverdlov ED (2007). Only those genes of the KIAA1245 gene subfamily that contain HERV(K) LTRs in their introns are transcriptionally active. Virology 358 (1), 39–47
  36. Mashkova TD, Oparina NY, Zinoveva OL, Kropotova ES, Dubovaya VI, Poltaraus AB, Fridman MV, Kopantsev EP, Vinogradova TV, Zinoveva MV, Laktionov KK, Kasymova OT, Zborovskaya IB, Sverdlov ED, Kisselev LL (2006). Transcription of TIMP3, DAPK1, and AKR1B10 in squamous-cell lung cancer. Mol Biol 40 (6), 945–951
  37. Kovalskaya E, Buzdin A, Gogvadze E, Vinogradova T, Sverdlov E (2006). Functional human endogenous retroviral LTR transcription start sites are located between the R and U5 regions. Virology 346 (2), 373–378
  38. Buzdin A, Vinogradova T, Lebedev Y, Sverdlov E (2005). Genome-wide experimental identification and functional analysis of human specific retroelements. Cytogenet Genome Res 110 (14), 468–474
  39. Slizhikova DK, Vinogradova TV, Sverdlov ED (2005). The NOLA2 and RPS3A genes as highly informative markers of human squamous cell carcinoma of lung. Russ. J. Bioorganic Chem. 31 (2), 178–182
  40. Nadezhdin EV, Vinogradova TV, Sverdlov ED (2004). A comparative analysis of regulatory regions of the transthyretin gene in the mouse, human, and chimpanzee genomes. Russ. J. Bioorganic Chem. 30 (4), 344–348
  41. Buzdin A, Gogvadze E, Kovalskaya E, Volchkov P, Ustyugova S, Illarionova A, Fushan A, Vinogradova T, Sverdlov E (2003). The human genome contains many types of chimeric retrogenes generated through in vivo RNA recombination. Nucleic Acids Res 31 (15), 4385–4390
  42. Vinogradova TV, Zhulidov PA, Illarionova AE, Sverdlov ED (2002). A new family of KIAA1245 genes with and without HERV-K LTRs in their introns. Russ. J. Bioorganic Chem. 28 (4), 312–315
  43. Buzdin A, Ustyugova S, Gogvadze E, Vinogradova T, Lebedev Y, Sverdlov E (2002). A new family of chimeric retrotranscripts formed by a full copy of U6 small nuclear RNA fused to the 3′ terminus of L1. Genomics 80 (4), 402–406
  44. Buzdin A, Khodosevich K, Mamedov I, Vinogradova T, Lebedev Y, Hunsmann G, Sverdlov E (2002). A technique for genome-wide identification of differences in the interspersed repeats integrations between closely related genomes and its application to detection of human-specific integrations of HERV-K LTRs. Genomics 79 (3), 413–422
  45. Vinogradova T, Leppik L, Kalinina E, Zhulidov P, Grzeschik KH, Sverdlov E (2001). Selective Differential Display of RNAs containing Interspersed Repeats: Analysis of changes in the transcription of HERV-K LTRs in germ cell tumors. Mol Genet Genomics 266 (5), 796–805
  46. Vinogradova TV, Leppik LP, Nikolaev LG, Akopov SB, Kleiman AM, Senyuta NB, Sverdlov ED (2001). Solitary human endogenous retroviruses-K LTRs retain transcriptional activity in Vivo, the mode of which is different in different cell types. Virology 290 (1), 83–90
  47. Nadezhdin EV, Vinogradova TV, Sverdlov ED (2001). Interspecies subtractive hybridization of cDNA from human and chimpanzee brains. Dokl Biochem Biophys 381 (0), 415–418
  48. Lebedev YB, Belonovitch OS, Zybrova NV, Khil PP, Kurdyukov SG, Vinogradova TV, Hunsmann G, Sverdlov ED (2000). Differences in HERV-K LTR insertions in orthologous loci of humans and great apes. Gene 247 (12), 265–277
  49. Lagutin OV, Dobrovolsky VN, Vinogradova TV, Kyndiakov BN, Khodarovich YM, Jenkins N, James D, Markham N, Larionov OA (1999). Efficient human IFN-γ expression in the mammary gland of transgenic mice. J Interferon Cytokine Res 19 (2), 137–144
  50. Lavrentieva I, Khil P, Vinogradova T, Akhmedov A, Lapuk A, Shakhova O, Lebedev Y, Monastyrskaya G, Sverdlov ED (1998). Subfamilies and nearest-neighbour dendrogram for the LTRs of human endogenous retroviruses HERV-K mapped on human chromosome 19: Physical neighbourhood does not correlate with identity level. Hum Genet 102 (1), 107–116
  51. Vinogradova T, Volik S, Lebedev Y, Shevchenko Y, Lavrentyeva I, Khil P, Grzeschik KH, Ashworth LK, Sverdlov E (1997). Positioning of 72 potentially full size LTRs of human endogenous retroviruses HERV-K on the human chromosome 19 map. Occurrences of the LTRs in human gene sites. Gene 199 (12), 255–264