Evgenij P. Kopancev

Ph.D. (biological sciences)


Senior research fellow (Laboratory of human genes structure and functions)

Phone: +7 (495) 3307029

E-mail: kopantzev@ibch.ru

Selected publications

  1. Gnatenko DA, Kopantzev EP, Sverdlov ED (2018). Variable Effects of Growth Factors on Developmental Gene Expression in Pancreatic Cancer Cells. Dokl Biochem Biophys 481 (1), 217–218
  2. Kondratyeva LG, Chernov IP, Zinovyeva MV, Egorov VI, Kopantzev EP, Sverdlov ED (2018). Heterogeneous Expression of Embryonal Development Master Regulator SOX9 in Patients with Pancreatic Cancer. Dokl Biochem Biophys 481 (1), 208–211
  3. Gnatenko DA, Kopantsev EP, Sverdlov ED (2017). Fibroblast growth factors and pancreas organogenesis. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 11 (4), 341–348
  4. Kondratyeva LG, Kashkin KN, Chernov IP, Stukacheva EA, Dydich DA, Kopantzev EP, Sverdlov ED (2017). PCNA: A Constitutive Human Promoter for Gene Expression for Functional Studies and Therapeutic Applications. Mol. Gen. Microbiol. Virol. 32 (3), 137–140
  5. Kondratyeva LG, Didych DA, Chernov IP, Kopantzev EP, Stukacheva EA, Vinogradova TV, Sverdlov ED (2017). Dependence of expression of regulatory master genes of embryonic development in pancreatic cancer cells on the intracellular concentration of the master regulator PDX1. Dokl Biochem Biophys 475 (1), 259–263
  6. Kopantzev EP, Grankina EV, Kopantseva MR, Sverdlov ED (2017). The IGF-I/IGF-IR Signaling System and Pancreatic Cancer. Mol. Gen. Microbiol. Virol. 32 (3), 131–136
  7. Kondratyeva LG, Chernov IP, Zinovyeva MV, Kopantzev EP, Sverdlov ED (2017). Expression of master regulatory genes of embryonic development in pancreatic tumors. Dokl Biochem Biophys 475 (1), 250–252
  8. Abjalimov IR, Zinovyeva MV, Nikolaev LG, Kopantzeva MR, Kopantzev EP, Sverdlov ED (2017). Expression of transcription factor genes in cell lines corresponding to different stages of pancreatic cancer progression. Dokl Biochem Biophys 475 (1), 267–270
  9. Gnatenko DA, Kopantsev EP, Sverdlov ED (2017). The role of the signaling pathway FGF/FGFR in pancreatic cancer. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 11 (2), 101–110
  10. Gnatenko DA, Kopantzev EP, Sverdlov ED (2017). Fibroblast growth factors and their effects in pancreas organogenesis. Biomed Khim 63 (3), 211–218
  11. Kopantsev EP, Kostina MB, Grankina EV, Kopantseva MR, Egorov VI, Sverdlov ED (2016). Expression of therapeutic gene FCU1 sensitizes pancreatic cancer cells to 5-fluorocytosine and enhances the cytotoxic effect of 5-fluorouracil. Bull Exp Biol Med 161 (6), 808–810
  12. Shepelev MV, Kopantzev EP, Vinogradova TV, Sverdlov ED, Korobko IV (2016). hTERT and BIRC5 gene promoters for cancer gene therapy: A comparative study. Oncol Lett 12 (2), 1204–1210
  13. Kondratyeva LG, Sveshnikova AA, Grankina EV, Chernov IP, Kopantseva MR, Kopantzev EP, Sverdlov ED (2016). Downregulation of expression of mater genes SOX9, FOXA2, and GATA4 in pancreatic cancer cells stimulated with TGFβ1 epithelial–mesenchymal transition. Dokl Biochem Biophys 469 (1), 257–259
  14. Gnatenko DA, Kopantsev EP, Sverdlov ED (2016). Role of fibroblast growth factors in pancreatic cancer. Biomed Khim 62 (6), 622–629
  15. Alekseenko IV, Snezhkov EV, Chernov IP, Pleshkan VV, Potapov VK, Sass AV, Monastyrskaya GS, Kopantzev EP, Vinogradova TV, Khramtsov YV, Ulasov AV, Rosenkranz AA, Sobolev AS, Bezborodova OA, Plyutinskaya AD, Nemtsova ER, Yakubovskaya RI, Sverdlov ED (2015). Therapeutic properties of a vector carrying the HSV thymidine kinase and GM-CSF genes and delivered as a complex with a cationic copolymer. J Transl Med 13 (1), 78
  16. Zinovyeva MV, Kostina MB, Monastyrskaya GS, Sass AV, Filyukova OB, Vinogradova TV, Kopantzev EP, Sverdlov ED (2015). Genetic markers for lung and esophagus common precursor cells in human development. Dokl Biochem Biophys 463 (1), 203–208
  17. Sverdlov ED, Pleshkan VV, Alekseenko IV, Vinogradova TV, Kopantsev EP, Didych DA (2015). Adult stem cells and other cancer residents. Part I. Mol. Gen. Microbiol. Virol. 30 (3), 107–113
  18. Kuzmich AI, Kopantsev EP, Vinogradova TV, Sverdlov ED (2014). Comparative activity of several promoters in driving NIS expression in melanoma cells. Mol Biol 48 (1), 121–129
  19. Shubin AV, Lunina NA, Shedova EN, Roshina MP, Demidyuk IV, Vinogradova TV, Kopantsev EP, Chernov IP, Kostrov SV (2013). Evaluation of the toxic effects evoked by the transient expression of protease genes from human pathogens in HEK293 cells. APPL BIOCHEM MICRO+ 49 (9), 750–755
  20. Kuzmich AI, Vvedenskii AV, Kopantzev EP, Vinogradova TV (2013). Quantitative comparison of gene co-expression in a bicistronic vector harboring IRES or coding sequence of porcine teschovirus 2A peptide. Russ. J. Bioorganic Chem. 39 (4), 406–416
  21. Kashkin KN, Chernov IP, Stukacheva EA, Kopantzev EP, Monastyrskaya GS, Uspenskaya NY, Sverdlov ED (2013). Cancer specificity of promoters of the genes involved in cell proliferation control. Acta Naturae 5 (3), 79–83
  22. Shepelev MV, Korobko EV, Vinogradova TV, Kopantsev EP, Korobko IV (2013). LY294002 enhances expression of proteins encoded by recombinant replication-defective adenoviruses via mTOR- and non-mTOR-dependent mechanisms. Mol Pharm 10 (3), 931–939
  23. Kashkin KN, Chernov IP, Stukacheva EA, Kopantzev EP, Monastyrskaya GS, Uspenskaya NY, Sverdlov ED (2013). Cancer specificity of promoters of the genes involved in cell proliferation control. Acta Naturae 5 (18), 79–83
  24. Usova EV, Kopantseva MR, Kostina MB, Vankovich AN, Egorov VI, Kopantsev EP (2013). Expression of the ZEB2 gene in pancreatic stromal cells in pancreatic ductal adenocarcinoma, pancreatitis, and normal state. Dokl Biol Sci 448 (1), 61–64
  25. Durymanov MO, Beletkaia EA, Ulasov AV, Khramtsov YV, Trusov GA, Rodichenko NS, Slastnikova TA, Vinogradova TV, Uspenskaya NY, Kopantsev EP, Rosenkranz AA, Sverdlov ED, Sobolev AS (2012). Subcellular trafficking and transfection efficacy of polyethylenimine- polyethylene glycol polyplex nanoparticles with a ligand to melanocortin receptor-1. J Control Release 163 (2), 211–219
  26. Alekseenko IV, Pleshkan VV, Kopantzev EP, Stukacheva EA, Chernov IP, Vinogradova TV, Sverdlov ED (2012). Activity of the Upstream Component of Tandem TERT/Survivin Promoters Depends on Features of the Downstream Component. PLoS One 7 (10), e46474
  27. Alekseenko IV, Kopantzev EP, Vinogradova TV, Sverdlov ED (2011). Bicistronic vector for combined expression of the HSVtk killer gene and cytokine GM-CSF gene in cancer cells. Dokl Biochem Biophys 439 (1), 174–177
  28. Pavlyukov MS, Antipova NV, Balashova MV, Vinogradova TV, Kopantzev EP, Shakhparonov MI (2011). Survivin monomer plays an essential role in apoptosis regulation. J Biol Chem 286 (26), 23296–23307
  29. Kashkin KN, Musatkina EA, Komelkov AV, Tonevitsky EA, Sakharov DA, Vinogradova TV, Kopantsev EP, Zinovyeva MV, Favorskaya IA, Kainov YA, Aushev VN, Zborovskaya IB, Tonevitsky AG, Sverdlov ED (2011). Genes potentially associated with Cisplatin resistance of lung cancer cells. Dokl Biochem Biophys 438 (1), 147–150
  30. Kashkin KN, Musatkina EA, Komelkov AV, Sakharov DA, Trushkin EV, Tonevitsky EA, Vinogradova TV, Kopantzev EP, Zinovyeva MV, Kovaleva OV, Arkhipova KA, Zborovskaya IB, Tonevitsky AG, Sverdlov ED (2011). Genes Potentially Associated with Resistance of Lung Cancer Cells to Paclitaxel. Dokl Biochem Biophys 437 (1), 105–108
  31. Kuzmin DV, Vinogradova TV, Kopantzev EP, Sverdlov ED (2010). Cre-LoxP mediated strong enhancement of pBIRC5 promoter driven suicide of cancer cells with CD/UPRT and fluorocytosine. Open Gene Ther J 3 (0), 31–39
  32. Mingaleeva RN, Chernov IP, Kopantzev EP, Zavalova LL, Sass AV, Sverdlov ED (2010). Comparative analysis of herpes simplex virus thymidine kinase gene expression potentiation via HIV-1 Tat-TAR system and cancer-specific promoters in P53(+) and P53(-) cells. Mol Biol 44 (3), 448–453
  33. Kopantzev EP, Vayshlya NA, Kopantseva MR, Egorov VI, Pikunov M, Zinovyeva MV, Vinogradova TV, Zborovskaya IB, Sverdlov ED (2010). Cellular and molecular phenotypes of proliferating stromal cells from human carcinomas. Br J Cancer 102 (10), 1533–1540
  34. Zinovyeva MV, Monastyrskaya GS, Kopantzev EP, Vinogradova TV, Kostina MB, Sass AV, Filyukova OB, Uspenskaya NY, Sukhikh GT, Sverdlov ED (2010). Identification of some human genes oppositely regulated during esophageal squamous cell carcinoma formation and human embryonic esophagus development. Dis Esophagus 23 (3), 260–270
  35. Kashkin KN, Musatkina EA, Komelkov AV, Favorskaya IA, Trushkin EV, Shleptsova VA, Sakharov DA, Vinogradova TV, Kopantzev EP, Zinovyeva MV, Kovaleva OV, Zborovskaya IB, Tonevitsky AG, Sverdlov ED (2010). Expression profiling and putative mechanisms of resistance to doxorubicin of human lung cancer cells. Dokl Biochem Biophys 430 (1), 20–23
  36. Mityaev MV, Kopantzev EP, Buzdin AA, Vinogradova TV, Sverdlov ED (2010). Enhancer element potentially involved in human survivin gene promoter regulation in lung cancer cell lines. Biochemistry (Mosc) 75 (2), 182–191
  37. Kudriavtseva AV, Anedchenko EA, Oparina NY, Krasnov GS, Kashkin KN, Dmitriev AA, Zborovskaya IB, Kondratjeva TT, Vinogradova EV, Zinovyeva MV, Kopantsev EP, Senchenko VN (2009). Expression of FTL and FTH genes encoding ferritin subunits in lung and renal carcinomas. Mol Biol 43 (6), 972–981
  38. Mingaleeva RN, Chernov IP, Kopantsev EP, Stukacheva EA, Skaptseva NV, Sverdlov ED (2009). Study of transactivation effect on transcription by Tat-TAR system of human immunodeficiency virus type i (HIV-I) in nonlymphoid cells HEK293 and Calu-1. Mol. Gen. Microbiol. Virol. 24 (2), 56–60
  39. Zinoveva MV, Vaishlya NA, Vinogradova TV, Kopantsev EP, Sverdlov ED (2009). Structure and functions of isoforms of polyfunctional tumoral suppressor PML. Mol. Gen. Microbiol. Virol. 24 (2), 61–67
  40. Kopantzev EP, Melekhina OV, Kopantseva MR, Mochalnikova VV, Vinogradova TV, Egorov VI, Zborovskaia IB, Fedorov AV, Sverdlov ED (2009). Secreted growth factors from stromal fibroblasts of the human lung and pancreatic carcinomas. Dokl Biol Sci 429 (1), 583–586
  41. Anedchenko EA, Dmitriev AA, Krasnov GS, KondratEva OO, Kopantsev EP, Vinogradova TV, ZinovEva MV, Zborovskaya IB, Polotsky BE, Sacharova OV, Kashuba VI, Zabarovsky ER, Senchenko VN (2008). Downregulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1, and HYAL2 in non-small cell lung cancer. Mol Biol 42 (6), 859–869
  42. Kalinichenko SV, Kopantzev EP, Korobko EV, Palgova IV, Zavalishina LE, Bateva MV, Petrov AN, Frank GA, Sverdlov ED, Korobko IV (2008). Pdcd4 protein and mRNA level alterations do not correlate in human lung tumors. Lung Cancer 62 (2), 173–180
  43. Mityaev MV, Kopantzev EP, Buzdin AA, Vinogradova TV, Sverdlov ED (2008). Functional significance of a putative Sp1 transcription factor binding site in the survivin gene promoter. Biochemistry (Mosc) 73 (11), 1183–1191
  44. Kopantzev EP, Monastyrskaya GS, Vinogradova TV, Zinovyeva MV, Kostina MB, Filyukova OB, Tonevitsky AG, Sukhikh GT, Sverdlov ED (2008). Differences in gene expression levels between early and later stages of human lung development are opposite to those between normal lung tissue and non-small lung cell carcinoma. Lung Cancer 62 (1), 23–34
  45. Vayshlya NA, Zinovyeva MV, Sass AV, Kopantzev EP, Vinogradova TV, Sverdlov ED (2008). Increased expression of BIRC5 in non-small cell lung cancer and esophageal squamous cell carcinoma does not correlate with the expression of its inhibitors SMAC/DIABLO and PML. Mol Biol 42 (4), 579–587
  46. Mashkova TD, Oparina NY, Zinoveva OL, Kropotova ES, Dubovaya VI, Poltaraus AB, Fridman MV, Kopantsev EP, Vinogradova TV, Zinoveva MV, Laktionov KK, Kasymova OT, Zborovskaya IB, Sverdlov ED, Kisselev LL (2006). Transcription of TIMP3, DAPK1, and AKR1B10 in squamous-cell lung cancer. Mol Biol 40 (6), 945–951
  47. Shagin DA, Barsova EV, Bogdanova EA, Britanova OV, Gurskaya NG, Lukyanov KA, Matz MV, Punkova NI, Usman NY, Kopantzev EP, Salo E, Lukyanov SA (2002). Identification and characterization of a new family of C-type lectin-like genes from planaria Girardia tigrina. Glycobiology 12 (8), 463–472
  48. Domansky AN, Kopantzev EP, Snezhkov EV, Lebedev YB, Leib-Mosch C, Sverdlov ED (2000). Solitary HERV-K LTRs possess bi-directional promoter activity and contain a negative regulatory element in the U5 region. FEBS Lett 472 (23), 191–195
  49. Lukyanov KA, Gurskaya NG, Kopantsev EP, Lukyanov SA (1996). Selective Amplification of Evolutionarily Conserved Expressed Sequences. Bioorg Khim 22 (1), 53
  50. Lukyanov KA, Gurskaya NG, Kopantsev EP, Lukyanov SA (1996). Selective amplification of evolutionarily conserved expressed sequences. Russ. J. Bioorganic Chem. 22 (1), 43–47
  51. Kopantsev EP, Nesterova TB, Borodin AM, Zakiyan SM (1993). Construction of a mapping panel of human-rodent hybrid cells. Genetika 29 (9), 1440–1452