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Molecular Neurobiology Department seminar

The seminar will take place on February 2 at 15:00 in the Minor hall. Professor Kirill Volynski from the Institute of Neurology, University College London (UK) will talk about the regulation of neurotransmitter release. Everyone is cordially invited.

February 2 (This event is over)

neurotransmitter, exocytosis, synapse, calcium, synaptic vesicle

Vassilevski Alexander

Speaker: professor Kirill Volynski, Institute of Neurology, University College London (UK)

Presentation title: Regulation of synaptic vesicle exocytosis by Ca2+-sensitive Synaptotagmin 1 oligomers

Author's abstract:

Synaptic vesicular release of neurotransmitters forms the basis of information transfer in the brain. This process involves highly specialised machinery optimised for speed and coupled to the action potential-evoked presynaptic Ca2+ influx via the vesicular Ca2+ release sensor synaptotagmin (Syt1 and Syt2 in different types of synapses). Although the critical role of Syt1 was established more than 20 years ago, the precise sequence of molecular events that leads to fast synaptic vesicle exocytosis after Ca2+ binding by Syt1 remains unclear. Recently, James Rothman group in Yale has demonstrated that Syt1 molecules readily form Ca2+-sensitive ring-like oligomers on lipid surfaces (Wang et al. PNAS 2015, Zanetti et al. Elife 2016). This prompted a hypothesis that such Ca2+-dependent Syt1 oligomerization at the interface of the docked synaptic vesicle may play a critical role in regulation of neurotransmitter release. Here, I will present our new functional data arguing that Syt1 oligomerization is indeed essential for synchronisation of transmitter release in central synapses.

Chair: Alexey Semyanov; E-mail: semyanov@ibch.ru

january 15