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Scientists at the IBCh RAS have developed a drug for the treatment of multiple sclerosis
A team of scientists from the Institute of Bioorganic Chemistry RAS, Xenetic Biosciences Inc., OJSC Pharmsynthez and Center of multiple sclerosis and AID of St. Petersburg City Clinical Hospital №31 has created a new form of the drug used for the treatment of one of the most severe neurodegenerative autoimmune diseases. The drug has successfully passed pre-clinical trials and two clinical stages. If the results of the third stage of the clinical trials would be positive, the dug shall officially be passed into circulation to be used for the treatment of patients with multiple sclerosis. The results are published in the Neurotherapeutics journal.
Multiple sclerosis (MS) is a neurodegenerative disease in which the myelin (protective) sheath of nerve fibers becomes damaged. This process leads to a gradual loss of the different functions of the nervous system that are associated with the physical and psycho-emotional state of the patient. In Russia, the disease affects more than 200 thousand people between the ages of 15-25 years, which makes it a complex social problem.
– Many laboratories around the world are working on finding effective solutions for the treatment and therapy of multiple sclerosis, – says Alexey Belogurov, PhD in Chemistry, Senior Research Associate at the Laboratory of Biocatalysis of the Institute of Bioorganic Chemistry of the Russian Academy of Sciences, one of the authors of the article. – Despite the prevalence of the disease, there is no ideal drug for its treatment, and most of the drugs cause side effects. In Russia, absolute majority of the drugs are purchased abroad using budget funds. For example, one of the most popular drugs costs up to more than 3 billion rubles annually. It is obvious that, in order to solve social and economic problems, it is necessary to create high-quality domestic medications, and this is what we are now doing.
Scientists from the Institute of Bioorganic Chemistry of the Russian Academy of Sciences proposed a drug whose main component are liposomes (lipid vesicle conveyers). They contain fragments of myelin protein, which performs the role of the structural sheath of nerve fibers in the body. In the experiment, three protein fragments were selected, one of which has a therapeutic effect in the early stages of the disease, and the other two are used to prevent the development of pathologies during the remission stage. In the laboratory, it was found that the most effective option is the co-administration of all three fragments inside mannosylated liposomes.
Preclinical tests were carried out on Dark Agouti (DA) rats suffering from experimental autoimmune encephalomyelitis, which is similar to multiple sclerosis in humans. The results established the positive effect of the myelin protein fragments. They then tried to develop a drug. Previous laboratory achievements were implemented in the development of the drug, and in particular, the myelin protein fragment encapsulation technique i.e. an environment of unilamellar liposome peptides.
– The drugs were tested in a series of clinical trials on healthy volunteers and patients suffering from multiple sclerosis. These trials were conducted at five national centers in Russia. We discovered that the drug is well tolerated, and has a very low probability of developing adverse events, – remarks Alexey.
Even in the 2006-2008 period, laboratory researchers were able to demonstrate the significance of the myelin basic protein and its prospects for use in research and in the treatment of multiple sclerosis. During that time, scientists investigated autoantibodies from blood serum collected from patients suffering from multiple sclerosis and from laboratory animals that were developing experimental autoimmune encephalitis. This series of works was the starting point in the development of an effective treatment for this disease.
All that remains is to wait for the results of the final phase of the clinical trials, which shall allow the new drug to enter into clinical practice for the treatment of multiple sclerosis.
june 23, 2016