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- Spider venom will cure from paralysis
Scientists from IBCh RAS together with foreign colleagues discovered that a toxin from the venom of the spider Heriaeus melloteei may serve as a hit in drug discovery for hypokalemic periodic paralysis type 2. The disease is caused by mutations in the gene encoding voltage-gated sodium channels NaV1.4, characteristic of skeletal muscles. As a result of the mutations, these channels conduct aberrant currents, the muscles are unable to respond to the signals of the nervous system, and weakness develops followed by paralysis. Until now, there is no reliable medication for all cases of this disease. The results of the work are published in the Proceedings of the National Academy of Sciences of the USA (PNAS).
- Lindoldhamine can activate the human ASIC3 channel
Researchers from the Laboratory of Neuroreceptors and Neuroregulators (group leader - Sergei Kozlov) found alkaloid lindoldhamine in the leaves of the noble laurel, which can activate the human ASIC3 channel at physiological pH.
- Open call for research fellowships in Systems Biology
The Skoltech Center for Data Intensive Biomedicine and Biotechnology is proud to announce for the third time an open call for research fellowships in Systems Biology. Application period: 20 February 2018 to 15 March 2018 (Deadline: 23:59, Moscow time). The total amount of support is 630,000 rubles per year. Period: 3-year. Deadline: 15-03-2018 23:59 For more information on who is eligible to apply, how to apply, and available funding, please click here.
- Academician A.G. Gabibov and Professor J. Schlessinger handed over the Lomonosov Great Gold Medal to Professor Sidney Altman
October 13, 2017
Acting Director of the Institute of Bioorganic Chemistry RAS, President of the Russian Biochemistry and Molecular Biology Society, academician Alexander Gabibov and the head of the Pharmacology Department at Yale University, a member of the US National Academy of Sciences and a foreign member of the RAS, member of the International Advisory Board of Institute of Bioorganic Chemistry of the RAS Joseph Schlessinger on behalf of the President of the Russian Academy of Sciences awarded the Lomonosov Great Gold Medal to the laureate of 2016, Professor at Yale University, a member of the International Advisory Board of Institute of Bioorganic Chemistry RAS, Nobel Prize laureate Sidney Altman. Professor Altman has received the award "for outstanding contribution to the field of biochemistry of nucleic acids, the discovery of the catalytic activity of the nucleic acids and the creation of new biologically active substances."
- The international forum was held at the IBCh RAS
October 12, 2017
The Joint Life Sciences Forum, including the International Scientific Conference in bioorganic chemistry "XII conference dedicated to the Memory of Academician Yuri A. Ovchinnikov" and the VIII Russian Symposium "Proteins and Peptides" with a Young Scientists Competition, was held at the Institute of Bioorganic Chemistry RAS at 18-22 September, 2017. The leading foreign experts who visited the forum named it one of the main scientific events in the field of Life Sciences in the world in this year.
- Laboratory of the IBCh first in Russia received a foreign order for preclinical testing of substances by world standards
October 5, 2017
Laboratory of Biological Tests of the Branch of the Institute of Bioorganic Chemistry (BICh) received an order from a European company for preclinical animal studies, which will be conducted in accordance with world standards. Thus, for the first time, Russia will export high-tech services such as pre-clinical research for foreign countries.
- Scientists made proteins shine longer
September 1, 2017
Russian scientists together with foreign colleagues extended the shine time of fluorescent label in live cells. Light is emitted longer due to the continuous exchange of fluorogenic dyes interacting with special protein labels. The method which was described in the Chemical Science journal will simplify the live cells staining and provide new opportunities for research. This work was supported by the Russian Science Foundation.
- Researchers from IBCh found out how the protein isoforms diverse
August 16, 2017
Researchers of the IBCh RAS and the Federal Research and Clinical center of Physical-Chemical Medicine of FMBA of Russia found that alternative splicing of messenger RNAs makes a non-significant contribution to the plant cell proteome diversity. The results have been published in the Scientific Reports journal.
- Chemists discovered a new mechanism of action of a Vipera nikolskii venom neurotoxin
June 8, 2017
Scientists from the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS (IBCh RAS) with the participation of colleagues from the Institute of Human Morphology of RAMS and the Pirogov RSMU found that the enzyme phospholipase A2 from the Vipera nikolskii venom is able to adhere to lipid membranes (prototypes of cell membranes) and cause their aggregation, even if the activity of enzyme is specifically blocked. It turned out that this is due to the presence of two binding sites in the enzyme structure. Published in the journal Toxicon the results of the work help to understand how the multicomponent snakes’ venoms work.
- The researchers of the IBCh RAS took part at the international conference nAChR 2017
May 31, 2017
From 7 to 11 May the fourth international conference on nicotinic acetylcholine receptors (nAChR 2017) was held on the island of Crete (Greece) in which scientists from the Institute of Bioorganic Chemistry RAS took part. Together with other leading experts in the field of neurobiology associated with cholinergic transmission, they discussed the genetic, molecular, structural and cellular aspects of research and told what key trends in the development of this scientific area are actively supported now.
- Russian scientists study to control a neural network through infrared radiation
May 26, 2017
Researcher from the Institute of Bioorganic Chemistry of the Russian Academy of Sciences together with their colleagues have developed a method for stimulating neurons with infrared radiation. They implemented in mice neurons snake proteins that react to temperature – thermoreceptors. Published in Nature Communications journal results will help non-invasive stimulate neural networks in the deep layers of tissues in the body, as well as control the activity of other types of cells in living systems. In the future, it can help in the therapy of various nervous system diseases.
- Peptides from marine anemones gave analgesic effect
May 22, 2017
Researchers from the Institute of Bioorganic Chemistry RAS together with their colleagues have isolated the analgesic peptides Ms9a-1 and Ueq 12-1 from sea anemones, one of the most ancient predators on the planet. The ability of these substances to selectively enhance the activity of TRPA1 receptor opens up new opportunities for basic research and serves as a basis for the painkillers and anti-inflammatory drugs development. The research was supported by the Russian Science Foundation, and the results were published in the Journal of Biological Chemistry and Toxins.