Прошкина Галина Михайловна

Кандидат биологических наук


Старший научный сотрудник (Лаборатория молекулярной иммунологии)

Тел.: +7 (499) 724-71-88

Образование

Период обученияСтрана, городУчебное заведениеДополнительная информация
1994–1999 Россия, Москва МГАТХТ им. М.В. Ломоносова (факультет биотехнологии и органического синтеза, кафедра биотехнологии) Диплом биотехнолога с отличием
2006 Россия, Москва Институт биоорганической химии им. М.М. Шемякина и Ю.А. Овчинникова РАН Диплом кандидата биологических наук

Гранты и проекты

ПериодДополнительная информация
2002–2003 Грант РФФИ для молодых аспирантов и сотрудников

Избранные публикации

  1. Proshkina GM, Shramova EI, Shilova ON, Ryabova AV, Deyev SM (2018). Phototoxicity of flavoprotein miniSOG induced by bioluminescence resonance energy transfer in genetically encoded system NanoLuc-miniSOG is comparable with its LED-excited phototoxicity. J Photochem Photobiol B 188 (0), 107–115
  2. Deyev S, Proshkina G, Baryshnikova O, Ryabova A, Avishai G, Katrivas L, Giannini C, Levi-Kalisman Y, Kotlyar A (2018). Selective staining and eradication of cancer cells by protein-carrying DARPin-functionalized liposomes. Eur J Pharm Biopharm 130 (0), 296–305
  3. Shramova EI, Proshkina GM, Deyev SM (2018). The Cause of ErbB2 Receptor Resistance to Downregulation. Russ. J. Bioorganic Chem. 44 (3), 279–288
  4. Shipunova VO, Shilova ON, Shramova EI, Deyev SM, Proshkina GM (2018). A Highly Specific Substrate for NanoLUC Luciferase Furimazine Is Toxic in vitro and in vivo. Russ. J. Bioorganic Chem. 44 (2), 225–228
  5. Vorobyeva A, Bragina O, Altai M, Mitran B, Orlova A, Shulga A, Proshkina G, Chernov V, Tolmachev V, Deyev S (2018). Comparative Evaluation of Radioiodine and Technetium-Labeled DARPin 9-29 for Radionuclide Molecular Imaging of HER2 Expression in Malignant Tumors. Contrast Media Mol Imaging 2018 (0), 6930425
  6. Proshkina GM, Kiseleva DV, Shilova ON, Ryabova AV, Shramova EI, Stremovskiy OA, Deyev SM (2017). Bifunctional Toxin DARP-LoPE Based on the Her2-Specific Innovative Module of a Non-Immunoglobulin Scaffold as a Promising Agent for Theranostics. Mol Biol 51 (6), 865–873
  7. Prokofjeva MM, Proshkina GM, Lebedev TD, Shulgin AA, Spirin PV, Prassolov VS, Deyev SM (2017). Lentiviral gene delivery to plasmolipin-expressing cells using Mus caroli endogenous retrovirus envelope protein. B SOC CHIM BIOL 142 (0), 226–233
  8. Proshkina GM, Kiseleva DV, Shilova ON, Ryabova AV, Shramova EI, Stremovskiy OA, Deyev SM (2017). Bifunctional Toxin DARP-LoPE Based on the HER2-Specific Innovative Module of a Non-Immunoglobulin Scaffold as a Promising Agent for Theranostics. Mol Biol (Mosk) 51 (6), 997–1007
  9. Deyev S, Proshkina G, Ryabova A, Tavanti F, Menziani MC, Eidelshtein G, Avishai G, Kotlyar A (2017). Synthesis, Characterization, and Selective Delivery of DARPin-Gold Nanoparticle Conjugates to Cancer Cells. Bioconjug Chem 28 (10), 2569–2574
  10. Shilova ON, Proshkina GM, Ryabova AV, Deyev SM, Petrov RV (2017). Cytotoxicity of targeted HER2-specific phototoxins based on flavoprotein miniSOG is determined by the rate of their internalization. Dokl Biochem Biophys 475 (1), 256–258
  11. Shramova EI, Proshkina GM, Deyev SM, Petrov RV (2017). Flavoprotein miniSOG BRET-induced cytotoxicity depends on its intracellular localization. Dokl Biochem Biophys 474 (1), 228–230
  12. Sokolova EA, Proshkina GM, Kutova OM, Balalaeva IV, Deyev SM (2017). The effect of the targeted recombinant toxin DARPin-PE40 on the dynamics of HER2-positive tumor growth. Acta Naturae 9 (3), 103–107
  13. Sokolova E, Proshkina G, Kutova O, Shilova O, Ryabova A, Schulga A, Stremovskiy O, Zdobnova T, Balalaeva I, Deyev S (2016). Recombinant targeted toxin based on HER2-specific DARPin possesses a strong selective cytotoxic effect in vitro and a potent antitumor activity in vivo. J Control Release 233 (0), 48–56
  14. Shramova EI, Proshkina GM, Chumakov SP, Khodarovich YM, Deyev SM (2016). Flavoprotein miniSOG Cytotoxisity Can Be Induced By Bioluminescence Resonance Energy Transfer. Acta Naturae 8 (4), 118–125
  15. Sokolova EA, Schulga AA, Stremovskiy OA, Balalaeva IV, Proshkina GM, Deyev SM (2016). Production and functional characteristics of the recombinant targeted toxin based on the HER2-specific non-immunoglobulin scaffold. BIOL MEMBRANY 33 (6), 429–434
  16. Shilova ON, Proshkina GM, Ryabova AV, Deyev SM (2016). Anti-HER2 phototoxin based on flavoprotein miniSOG causes the oxidative stress and necrosis of HER2-positive cancer cells. Moscow Univ Biol Sci Bull 71 (1), 14–18
  17. Proshkina GM, Stremovskiy OA, Sibrikova DV, Ryabova AV, Deyev SM (2016). A targeted toxin based on a binding module of non-immunoglobulin scaffold as a new agent for theranostics. Sovrem Tekhnologii Med 8 (4), 7–12
  18. Proshkina GM, Shilova ON, Ryabova AV, Stremovskiy OA, Deyev SM (2015). A new anticancer toxin based on HER2/neu-specific DARPin and photoactive flavoprotein miniSOG. B SOC CHIM BIOL 118 (0), 116–122
  19. Shilova ON, Proshkina GM, Lebedenko EN, Deyev SM (2015). Internalization and Recycling of the HER2 Receptor on Human Breast Adenocarcinoma Cells Treated with Targeted Phototoxic Protein DARPinminiSOG. Acta Naturae 7 (3), 126–32
  20. Shilova ON, Proshkina GM, Lebedenko EN, Deyev SM (2015). Internalization and Recycling of the HER2 Receptor on Human Breast Adenocarcinoma Cells Treated with Targeted Phototoxic Protein DARPinminiSOG. Acta Naturae 7 (3), 126–132
  21. Proshkina GM, Mironova KE, Deyev SM, Petrov RV (2015). Mechanism of the cytotoxic action of immunophototoxin 4D5scFV-miniSOG on HER2/neu-positive cancer cells. Dokl Biochem Biophys 460 (1), 16–19
  22. Mironova KE, Chernykh ON, Ryabova AV, Stremovskiy OA, Proshkina GM, Deyev SM (2014). Highly specific hybrid protein DARPin-mCherry for fluorescent visualization of cells overexpressing tumor marker HER2/neu. Biochemistry (Mosc) 79 (12), 1391–1396
  23. Mironova KE, Proshkina GM, Ryabova AV, Stremovskiy OA, Lukyanov SA, Petrov RV, Deyev SM (2013). Genetically encoded immunophotosensitizer 4D5scFv-miniSOG is a highly selective agent for targeted photokilling of tumor cells in vitro. Theranostics 3 (11), 831–840
  24. Proshkin SA, Shematorova EK, Souslova EA, Proshkina GM, Shpakovski GV (2011). A minor isoform of the human RNA polymerase II subunit hRPB11 (POLR2J) interacts with several components of the translation initiation factor eIF3. Biochemistry (Mosc) 76 (8), 976–980
  25. Proshkina GM, Shpakovskii GV (2009). Functional interaction of the RNA polymerase II Rpb11 subunit with the subunit Med18 (Srb5) of the Saccharomyces cerevisiae mediator complex. Russ. J. Bioorganic Chem. 35 (4), 518–522
  26. Proshkina GM, Shpakovskiǐ GV (2009). The functional interaction of an RNA polymerase II Rpb11 subunit with the Med18 subunit (Srb5) of the Saccharomyces cerevisiae mediator complex. Bioorg Khim 35 (4), 572–576
  27. Proshkina GM, Shematorova EK, Proshkin SA, Zaros C, Thuriaux P, Shpakovski GV (2006). Ancient origin, functional conservation and fast evolution of DNA-dependent RNA polymerase III. Nucleic Acids Res 34 (13), 3615–3624