- A new direction of synthetic chemistry was developed in the Institute of Bioorganic Chemistry RAS
Small molecules play a critical role in many biological processes and are used as drugs and other research tools.
- Why acupuncture increases pain threshold of the rodent?
Scientists from the Laboratory of neuroreceptors and neuroregulators helped colleagues from Chengdu University (China) to conduct a series of in vivo experiments on wild-type and knockout by pain sensing receptors TRPV1 and P2X7 animals. It was shown that a stimulation of ST36 acupuncture point leads to an analgesic effect in the model of inflammation from the introduction of a slightly acidic solution into the paw, similar to the effects of selective TRPV1 and ASIC3 ion channel inhibitors. In the model of inflammation from the administration of α, β-meATP (a P2X1,3 purinergic receptor agonist) the ST36 point stimulation also reduced pain sensitivity, but not so effective as the P2X3 antagonist A-317491 or different ASIC3 channel blockers. The results are published in the British Journal of Pharmacology.
- Deciphering Ribosomes’ Actions in Living Cells
December 30, 2019
Researchers from the Laboratory of Bioinformatics Approaches in Combinatorial Chemistry and Biology IBCH RAS, in collaboration with Irish colleagues, recently published a review in WIRES RNA that compiles the computational approaches, software tools, and data resources that have been developed over the last ten years for ribosome profiling data processing and analysis.
- The new method for T-cell receptor alpha chain clonality assessment can be used for minimal disease monitoring in leukemia
December 27, 2019
Monitoring of minimum residual disease (MRD) is one of the most important diagnostic tests in the treatment of acute and chronic lymphoblastic leukemia. Currently, several methods for MRD are used, the most sensitive of which is the assessment and monitoring of clonal rearrangements in the immunoglobulin genes characteristic of tumor cells. High sensitivity, up to 1 tumor cell per million, is achieved by using next generation highthroughput sequencing technology (Illumina).
- PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia
October 29, 2019
Protein arginine methyltransferase 5 (PRMT5) belongs to the class II arginine methyltransferases and catalyzes monomethylation and symmetrical dimethylation of arginines on proteins. It has recently emerged as a promising cancer drug target, and two PRMT5 inhibitors are currently in clinical trials for a range malignancies. Despite the recognized therapeutic potential, it is unclear which PRMT5 functions underlie its oncogenic activity.
- A previously unknown modulator of purinergic and FGF-signalization, c-Answer, that stimulates regeneration in cold-blooded animals was lost by poorly regenerating warm-blooded animals, including humans
October 18, 2019
A group of scientists from the Laboratory of Molecular Bases of Embryogenesis, IBCh RAS, together with colleagues from the Laboratory of Mathematical Methods and Models in Bioinformatics, IPPI RAS developed a bioinformatics method that allows one to reveal genes that appear or disappear at a certain stage of evolution. Using this method, a number of genes were found that disappeared in warm-blooded animals, including humans.
- Peptides encoded by short open reading frames regulate plant growth and development
September 5, 2019
All genomes contain millions of short open reading frames (<100 codons) that are discarded during genome annotation. Recently, it has been shown that peptides encoded by short open reading frames can perform many important functions in animal cells.
- The secret of fireworm is out: molecular basis of Odontosyllis bioluminescence
August 29, 2019
Researchers discovered the biomolecular mechanism of fireworm glow.
- Seminar by Prof. Ilya Vinnikov «The top-down strategy in deciphering the roles of microRNAs in the metabolic and neurodegenerative models»
August 17, 2019
Prof. Ilya Vinnikov from the Shanghai Jiao Tong University will deliver a lecture entitled «The top-down strategy in deciphering the roles of microRNAs in the metabolic and neurodegenerative models». Date and time: Tue 20 August 2019 14:00. Location: Conference hall at 5th floor BON IBCh.
- Unique CDR3 epitope targeting by CAR-T cells is a viable approach for treating T cell
April 26, 2019
Efficient and specific removal of malignant cells is the ultimate goal of cancer therapy. The current rapid development of chimeric antigen receptor T cell (CAR-T cell or CART) therapy potentially provides high efficiency and allows long-term surveillance, which have greatly extended the frontier of leukemia treatment.